Around 2005, 2C-B-FLY appeared and gained some popularity in the online research chemicals market before largely disappearing in October 2009. This was because a batch of Bromo-DragonFLY was accidentally mislabeled as 2C-B-FLY. Bromo-DragonFLY is dosed in micrograms while 2C-B-FLY is dosed in milligrams. This led to two deaths as a result of taking overdoses of Bromo-DragonFLY meant to be effective doses for 2C-B-FLY. This event led to its immediate withdrawal until around 2016 when it resurfaced on the market again.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-B-FLY. Thus, it has little history of human usage.
Due to its high potency and sensitive dose response, many reports also indicate that the effects of this substance should not be seen as a simple substitute for 2C-B.